德國殷格翰2019年7月10日 /美通社/ -- 勃林格殷格翰公司在澳大利亞墨爾本舉行的2019年國際血栓與止血學(xué)會（ISTH）年會上，對外公布了兩項(xiàng)使用達(dá)比加群治療兒童疾病的研究結(jié)果。[1],[2]
研究數(shù)據(jù)顯示，在治療兒童急性靜脈血栓栓塞（VTE）時，達(dá)比加群與目前的標(biāo)準(zhǔn)療法（SOC）擁有相似的療效與安全性。[1]另一項(xiàng)研究同樣證實(shí)了達(dá)比加群良好的安全性，這項(xiàng)研究首次評估了采用直接口服抗凝劑（DOAC）在存在持續(xù)性VTE風(fēng)險因素的兒童中預(yù)防復(fù)發(fā)性VTE的效果。[2]
目前，用于治療與預(yù)防兒童復(fù)發(fā)性VTE的標(biāo)準(zhǔn)療法存在一定的局限性，包括需要頻繁監(jiān)測與非口服給藥等。[2]上述針對達(dá)比加群的全新研究旨在為對VTE患兒及存在VTE復(fù)發(fā)風(fēng)險的兒童采用抗凝治療提供更多的洞見與專業(yè)知識。
勃林格殷格翰公司副總裁、心血管代謝領(lǐng)域臨床開發(fā)負(fù)責(zé)人Martina Bruckmann教授說：“多年來，VTE的診斷率與發(fā)病率都在急劇上升，兒童VTE的發(fā)病率很高。盡管目前我們擁有治療VTE的相關(guān)療法，但兒童患者仍需獲得有效、安全與更加便捷的治療選擇。因此，我們旨在研究達(dá)比加群在成人VTE患者中被證實(shí)的安全性與療效是否同樣適用于兒童患者。令人鼓舞的是，這些研究表明達(dá)比加群在兒童復(fù)發(fā)性VTE的潛在治療與預(yù)防上具有相似的安全性與療效?！?/p>
達(dá)比加群（泰畢全，Pradaxa）尚未在任何國家獲批用于治療VTE患兒。上述研究反映了勃林格殷格翰公司始終致力于拓展血栓疾病治療領(lǐng)域的科學(xué)知識。廣泛的RE-VOLUTION®臨床試驗(yàn)項(xiàng)目已充分證實(shí)達(dá)比加群在成人患者中的安全性與療效，并擁有大量臨床試驗(yàn)數(shù)據(jù)。[3]-[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]
參考文獻(xiàn)
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